Insciences J. 2014, 4(1), 1-18;doi:10.5640/insc.040101
Review Paper, Section: Sensors
Electrochemical Detection of Benzodiazepines, Following Liquid Chromatography, for Applications in Pharmaceutical, Biomedical and Forensic Investigations
Kevin C. Honeychurch1, John P. Hart1 * 
1 Centre for Research in Biosciences, University of the West of England, Bristol, BS16 1QY, UK
* Author to whom correspondence should be addressed.
Published: January 23, 2014
Complete Article
Abstract
Benzodiazepines are an important class of drugs commonly administered with a potential for abuse and environmental pollution. This review focuses on the liquid chromatographic electrochemical detection of the benzodiazepine class of drugs. These are characterised by a readily electrochemically reducible azomethine group, with a number also substituted by other electrochemically active groups. Liquid chromatography employing both single and dual electrode detection has been reported for a variety of benzodiazepines and their metabolites in biological, pharmaceutical, biomedical and forensic investigations. Recently, electrochemistry has been utilised to mimic biological oxidation processes and has been combined with liquid chromatography/mass spectroscopy for their identification and quantification of the products generated. The present review focuses on recent developments in liquid chromatographic- electrochemical determination of benzodiazepines reported since 2006, with earlier reports given in summary.
benzodiazepines, electrochemical detection, liquid chromatography, review, single and dual electrodes
