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About Stem Cells

The Stem Cells is a section published by the Insciences Journal (ISSN 1664-171X), an Open Access journal launched by Insciences Organisation. This section publishes High-quality original research papers and Reviews related to Stem Cells.

Insciences J. 2011, 1(4), 157-168;doi:10.5640/insc.0104157

Review Paper, Section: Stem Cells

Application of Human Pluripotent Stem Cells in T Cell Based Cancer Immunotherapy

Arvind Chhabra1 * email

1 Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA.

* Author to whom correspondence should be addressed.

Published: September 28, 2011

Complete Article

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Abstract

Human pluripotent stem cells represent a unique reservoir that could be utilized for generating cells of a given lineage. Cancer immunotherapy field could benefit from this, since one of the key limitations in developing an effective immune based cancer therapy is the lack of sufficient high avidity anti-tumor T cells in a great majority of cancer patients. The main reason for this is the fact that most human tumor antigens are “self-antigens” and most self reactive high avidity T cells are deleted during development to avoid autoimmunity. This manuscript reviews recent advances towards differentiating human pluripotent stem (hPS) cells into different immune effector cells, and potential strategies to utilize hPS cells in T cell based cancer immunotherapy approaches. We will also discuss the advantages and concerns associated with their clinical applications.

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